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Table 3 Comparative gene fold changes for all genes tested by injury group

From: Age exacerbates microglial activation, oxidative stress, inflammatory and NOX2 gene expression, and delays functional recovery in a middle-aged rodent model of spinal cord injury

Comparative fold change by injury group
Naïve Gene tested 30 dpi
3 months old 12 months old 3 months old 12 months old
1.467 ± 0.8292 **6.993 × 106 ± 1.258 × 106 CD86 1.096 ± 0.2886 ***1.253 × 106 ± 145,818
1.371 ± 0.5850 0.7830 ± 0.2167 CD206 1.104 ± 0.3465 **139,991 ± 24,361
2.217 ± 1.785 0.6052 ± 0.04079 p22PHOX 1.030 ± 0.1825 *20678 ± 6017
8.352 ± 8.037 ****39,131 ± 2480 p47PHOX 7.739 ± 5.672 *1.225 × 106 ± 473,918
0.9453 ± 0.05264 1.583 ± 0.4531 gp91PHOX 0.9421 ± 0.08263 *1.948 ± 0.4574
3.229 ± 2.839 163.1 ± 141.8 TNFα 0.6954 ± 0.3801 *11.55 ± 2.502
1.226 ± 0.5548 0.8387 ± 0.6209 NFκB 1.027 ± 0.1751 *4.108 ± 0.7734
44.06 ± 22.85 0.01669 ± 0.01419 iNOS 1.109 ± 0.3358 1.069 ± 0.4000
3.118 ± 2.773 1230 ± 794.0 Arg-1 1.047 ± 0.2304 1.382 ± 0.03944
0.4958 ± 0.4531 0.3324 ± 0.02472 CD68 1.104 ± 0.3346 1.011 ± 0.3394
2.438 ± 1.521 7.806 ± 4.643 IL10 1.051 ± 0.2427 1.057 ± 0.1975
  1. Table demonstrates how age affects gene expression before and after injury. The average of the 3-month-old group in both the naïve and injury groups was considered the control mean value. Each individual sample’s fold change was compared to the control mean. Fold changes are presented in table as mean values of all samples in each group ± SEM. N = 4/group
  2. *p < 0.05, **p < 0.005, ***p < 0.0005