Age exacerbates microglial activation, oxidative stress, inflammatory and NOX2 gene expression, and delays functional recovery in a middle-aged rodent model of spinal cord injury

Table 4 Comparative gene fold changes by age group for significantly impacted genes

Comparative fold change by age group
3 months old		Gene tested	12 months old
Naïve	30 dpi	Gene tested	Naïve	30 dpi
1.467 ± 0.8292	4.481 ± 1.179	CD86	0.6781 ± 0.3546	0.7444 ± 0.08664
1.731 ± 0.5850	0.7586 ± 0.5561	CD206	1.094 ± 0.3027	111,858 ± 67,300
1.043 ± 0.2966	225.2 ± 76.85	p22^PHOX	1.005 ± 0.06771	218.9 ± 132.1
1.491 ± 0.8159	3.134 ± 2.551	p47^PHOX	1.232 ± 0.4360	*180,416 ± 31,468
1.001 ± 0.02864	28.02 ± 3.662	gp91^PHOX	1.154 ± 0.3588	*54.89 ± 21.85

Table demonstrates the effect of injury on gene expression within age groups. The average of the naïve in both the 3- and 12-month-age groups was considered the control mean value. Each individual sample’s fold change was compared to the control mean. Fold changes are presented in the table as mean values of all samples in each group ± SEM. N = 4/group
*p < 0.005

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