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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Anti-inflammatory and immunomodulatory mechanisms of atorvastatin in a murine model of traumatic brain injury

Fig. 6

Effect of atorvastatin treatment on microglia/macrophage activation after TBI. a Representative immunohistochemical photomicrographs of Iba-1 stained microglia/macrophages in the peri-contusional cortex after TBI. Scale bar = 200 μm (upper,) and 100 μm (lower). Inset display high magnification images of a positive cell. Morphological observation showed that TBI provoked a drastic change in the morphology of microglia from the surveillant and ramified shape to a round and enlarged appearance. At 72 h after TBI, treatment with atorvastatin significantly reduced the soma size and ramification index. b Quantification of Iba-1 positive cells in the different groups. Atorvastatin-treated mice had significantly fewer activated microglia/macrophages compared with those in saline-treated mice at 72 h after TBI. Data are presented as the mean ± SD. ***p < 0.001 versus sham group, # p < 0.05 versus TBI + saline group. n = 6/group

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