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Table 1 Fatty acid composition of BV-2 cells treated with control vehicle, PC-DHA, or AceDoPC for 24 h. Values are expressed as means ± SEM (n = 4)

From: Docosahexaenoic acid-containing choline phospholipid modulates LPS-induced neuroinflammation in vivo and in microglia in vitro

  Control n = 4 PC-DHA n = 4 Acedo-PC n = 4 p value
  mg/100 mg fatty acids
 c12:0 3.1 ± 0.30 1.6 ± 0.79* 1.3 ± 0.54* 0.01
 c14:0 7.1 ± 0.23 5.4 ± 1.48 4.4 ± 1.27* 0.05
 c15:0 0.4 ± 0.03 0.4 ± 0.01 0.4 ± 0.02 0.46
 c16:0 23.9 ± 0.82 21.1 ± 1.83 21.5 ± 1.17 0.07
 c17:0 0.3 ± 0.01 0.3 ± 0.01 0.2 ± 0.01 0.54
 c18:0 9.3 ± 0.20 9.8 ± 0.43 10.5 ± 0.82 0.07
 c20:0 0.5 ± 0.30 0.2 ± 0.01 0.2 ± 0.02* 0.04
 c22:0 0.3 ± 0.04 0.3 ± 0.06 0.3 ± 0.02 0.13
 c24:0 0.9 ± 0.04 1.0 ± 0.09 0.9 ± 0.04 0.25
Saturated 45.6 ± 0.74 40.0 ± 3.56 39.7 ± 2.36* 0.04
 c16:1n-9 3.0 ± 0.07 3.4 ± 0.22* 3.2 ± 0.15 0.04
 c16:1n-7 2.5 ± 0.07 2.6 ± 0.12 2.7 ± 0.10 0.08
 c18:1 t 2.1 ± 0.36 0.8 ± 0.24*** 0.6 ± 0.04*** < 0.0001
 c18:1 n-9 22.3 ± 0.56 23.0 ± 1.40 23.5 ± 0.84 0.40
 c18:1 n-7 8.2 ± 0.14 9.1 ± 0.44* 9.4 ± 0.44** 0.01
 c20:1 n-9 0.6 ± 0.01 0.6 ± 0.07 0.6 ± 0.05 0.71
 c24:1 n-9 1.3 ± 0.03 1.5 ± 0.11a* 1.6 ± 0.10* 0.01
Monounsaturated 40.0 ± 0.80 41.0 ± 2.16 41.5 ± 1.53 0.52
 c18:2 n-6 0.3 ± 0.02 0.3 ± 0.03 0.3 ± 0.04 0.92
 c20:4 n-6 1.4 ± 0.08 1.4 ± 0.10 1.4 ± 0.09 0.86
 c22:4 n-6 0.2 ± 0.03 0.1 ± 0.02 0.1 ± 0.01 0.08
 c22:5 n-6 0.1 ± 0.02 0.1 ± 0.01 0.1 ± 0.01 0.07
n-6 2.0 ± 0.10 1.9 ± 0.10 1.9 ± 0.11 0.64
 c18:3 n-3 0.2 ± 0.01 0.2 ± 0.01 0.2 ± 0.02 0.26
 c22:5 n-3 0.3 ± 0.12 0.4 ± 0.22 0.4 ± 0.02 0.43
 c22:6 n-3 0.6 ± 0.08 3.7 ± 0.19*** 3.9 ± 0.11*** < 0.0001
n-3 1.1 ± 0.19 4.3 ± 0.21*** 4.6 ± 0.13*** < 0.0001
 c20:3 n-9 5.9 ± 0.07 6.3 ± 0.68 5.8 ± 0.44 0.34
Polyunsaturated 9.0 ± 0.32 12.5 ± 0.95*** 12.3 ± 0.61*** < 0.0001
 dma16:0 1.9 ± 0.03 2.5 ± 0.15** 2.5 ± 0.13*** < 0.0001
 dma18:0 0.9 ± 0.03 1.0 ± 0.12 1.1 ± 0.10 0.13
 dma18:1 n-9 1.4 ± 0.03 1.6 ± 0.13 1.5 ± 0.06 0.07
 dma18:1 n-7 1.2 ± 0.02 1.4 ± 0.08* 1.4 ± 0.08 0.02
DMA 5.4 ± 0.10 6.5 ± 0.48* 6.5 ± 0.35* 0.01
n-6/n-3 1.8 ± 0.26 0.4 ± 0.01*** 0.4 ± 0.01*** < 0.0001
  1. *p < 0.05, **p < 0.01, and ***p < 0.001 for comparison with control
  2. DMA dimethylacetals, PC phosphatidylcholine