Skip to main content

Table 1 Fatty acid composition of BV-2 cells treated with control vehicle, PC-DHA, or AceDoPC for 24 h. Values are expressed as means ± SEM (n = 4)

From: Docosahexaenoic acid-containing choline phospholipid modulates LPS-induced neuroinflammation in vivo and in microglia in vitro

 

Control n = 4

PC-DHA n = 4

Acedo-PC n = 4

p value

 

mg/100 mg fatty acids

 c12:0

3.1 ± 0.30

1.6 ± 0.79*

1.3 ± 0.54*

0.01

 c14:0

7.1 ± 0.23

5.4 ± 1.48

4.4 ± 1.27*

0.05

 c15:0

0.4 ± 0.03

0.4 ± 0.01

0.4 ± 0.02

0.46

 c16:0

23.9 ± 0.82

21.1 ± 1.83

21.5 ± 1.17

0.07

 c17:0

0.3 ± 0.01

0.3 ± 0.01

0.2 ± 0.01

0.54

 c18:0

9.3 ± 0.20

9.8 ± 0.43

10.5 ± 0.82

0.07

 c20:0

0.5 ± 0.30

0.2 ± 0.01

0.2 ± 0.02*

0.04

 c22:0

0.3 ± 0.04

0.3 ± 0.06

0.3 ± 0.02

0.13

 c24:0

0.9 ± 0.04

1.0 ± 0.09

0.9 ± 0.04

0.25

Saturated

45.6 ± 0.74

40.0 ± 3.56

39.7 ± 2.36*

0.04

 c16:1n-9

3.0 ± 0.07

3.4 ± 0.22*

3.2 ± 0.15

0.04

 c16:1n-7

2.5 ± 0.07

2.6 ± 0.12

2.7 ± 0.10

0.08

 c18:1 t

2.1 ± 0.36

0.8 ± 0.24***

0.6 ± 0.04***

< 0.0001

 c18:1 n-9

22.3 ± 0.56

23.0 ± 1.40

23.5 ± 0.84

0.40

 c18:1 n-7

8.2 ± 0.14

9.1 ± 0.44*

9.4 ± 0.44**

0.01

 c20:1 n-9

0.6 ± 0.01

0.6 ± 0.07

0.6 ± 0.05

0.71

 c24:1 n-9

1.3 ± 0.03

1.5 ± 0.11a*

1.6 ± 0.10*

0.01

Monounsaturated

40.0 ± 0.80

41.0 ± 2.16

41.5 ± 1.53

0.52

 c18:2 n-6

0.3 ± 0.02

0.3 ± 0.03

0.3 ± 0.04

0.92

 c20:4 n-6

1.4 ± 0.08

1.4 ± 0.10

1.4 ± 0.09

0.86

 c22:4 n-6

0.2 ± 0.03

0.1 ± 0.02

0.1 ± 0.01

0.08

 c22:5 n-6

0.1 ± 0.02

0.1 ± 0.01

0.1 ± 0.01

0.07

n-6

2.0 ± 0.10

1.9 ± 0.10

1.9 ± 0.11

0.64

 c18:3 n-3

0.2 ± 0.01

0.2 ± 0.01

0.2 ± 0.02

0.26

 c22:5 n-3

0.3 ± 0.12

0.4 ± 0.22

0.4 ± 0.02

0.43

 c22:6 n-3

0.6 ± 0.08

3.7 ± 0.19***

3.9 ± 0.11***

< 0.0001

n-3

1.1 ± 0.19

4.3 ± 0.21***

4.6 ± 0.13***

< 0.0001

 c20:3 n-9

5.9 ± 0.07

6.3 ± 0.68

5.8 ± 0.44

0.34

Polyunsaturated

9.0 ± 0.32

12.5 ± 0.95***

12.3 ± 0.61***

< 0.0001

 dma16:0

1.9 ± 0.03

2.5 ± 0.15**

2.5 ± 0.13***

< 0.0001

 dma18:0

0.9 ± 0.03

1.0 ± 0.12

1.1 ± 0.10

0.13

 dma18:1 n-9

1.4 ± 0.03

1.6 ± 0.13

1.5 ± 0.06

0.07

 dma18:1 n-7

1.2 ± 0.02

1.4 ± 0.08*

1.4 ± 0.08

0.02

DMA

5.4 ± 0.10

6.5 ± 0.48*

6.5 ± 0.35*

0.01

n-6/n-3

1.8 ± 0.26

0.4 ± 0.01***

0.4 ± 0.01***

< 0.0001

  1. *p < 0.05, **p < 0.01, and ***p < 0.001 for comparison with control
  2. DMA dimethylacetals, PC phosphatidylcholine
Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094