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Fig. 10 | Journal of Neuroinflammation

Fig. 10

From: Endogenous hydrogen sulphide attenuates NLRP3 inflammasome-mediated neuroinflammation by suppressing the P2X7 receptor after intracerebral haemorrhage in rats

Fig. 10

The effects of SAM and NaHS administration on neurological outcomes and brain edema in P2X7R-overexpressing rats at 1 and 3 days after ICH. a, b Modified Neurological Severity Score in the vehicle, Ad-GFP, Ad-P2X7R, Ad-P2X7R + SAM and Ad-P2X7R + NaHS groups at 1 and 3 days after ICH. c, d Brain water content assessment in the vehicle, Ad-GFP, Ad-P2X7R, Ad-P2X7R + SAM and Ad-P2X7R + NaHS groups at 1 and 3 days after ICH. Regarding the 3-day study of neurological outcomes and brain oedema in the setting of P2X7R overexpression after ICH, the neurological deficits and brain oedema were worse in the Ad-P2X7R group (p < 0.05), but not in the Ad-GFP group (p > 0.05 vs. vehicle), than in the vehicle group. Neurological deficits and brain oedema were significantly alleviated in the Ad-P2X7R + SAM and Ad-P2X7R + NaHS groups (p < 0.05 vs. Ad-P2X7R). N = 5 rats per group. Data are presented as the mean ± SEM. #p < 0.05 vs. vehicle; $p < 0.05 vs. Ad-P2X7R. SAM S-adenosyl-l-methionine, ICH intracerebral haemorrhage, Ad adenovirus, GFP green fluorescent protein

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