Skip to main content
Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Responses of rat and mouse primary microglia to pro- and anti-inflammatory stimuli: molecular profiles, K+ channels and migration

Fig. 8

Inward-rectifier (Kir) current versus activation state. Rat and mouse microglia were unstimulated (CTL) or stimulated for 30 h with IFN-γ and TNF-α (I + T), IL-4 or IL-10. Whole-cell Kir currents were recorded in response to a voltage protocol with test pulses between −175 and −65 mV in 10-mV increments from a holding potential of −15 mV. a Representative traces of total Kir current in primary rat (left column) and mouse (right column) microglia. b Scatterplot of individual cells showing the proportion of the peak inward current (at −135 mV) that was blocked by 20 μM ML133. c Current-voltage (I-V) relations for the total Kir current, where peak current density (pA/pF) was plotted as a function of voltage. Data are shown as mean ± SEM (number of cells). *p < 0.5; **p < 0.01; ***p < 0.001; ****p < 0.0001

Back to article page