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Table 6 mRNA expression of phagocytic and purinergic receptors and NOX enzymes

From: Responses of rat and mouse primary microglia to pro- and anti-inflammatory stimuli: molecular profiles, K+ channels and migration

 

Control

I + T

IL-4

IL-10

Relative RNA counts ± SD

Fold change with respect to Control

Rat

Mouse

Rat

Mouse

Rat

Mouse

Rat

Mouse

Cybb (NOX2)

3562 ± 601

7612 ± 1931

1.90 ↑↑↑

3.48 ↑↑↑ ***

0.53 ↓

0.44 ↓

1.45 **

0.69

Fcgr1a (CD64)

6419 ± 2158

1301 ± 184

0.40

6.59 ↑↑↑ ***

0.51

0.47

1.48

2.38

Fcgr2b (CD32)

5831 ± 1349

2995 ± 527

0.72

0.76

4.01 ↑↑↑ ***

0.98

3.57 ↑↑↑

3.93 ↑↑↑

Fcgr3a (CD16)

8307 ± 4638

3778 ± 968

3.77 ↑↑↑ ***

2.44 ↑↑↑

0.32

1.01

2.12 ↑↑↑

1.92 ↑

Msr1 (SR-A/CD204)

7024 ± 1385

3196 ± 511

0.10 ↓↓↓ ***

0.92

0.30 ↓↓↓ **

0.78

1.27

1.93 ↑↑↑ ***

Ncf1

8535 ± 2299

920 ± 80

6.03 ↑↑↑ ***

4.17 ↑↑↑

0.58

0.99

0.94

1.37

Nox1

14 ± 6

10 ± 3

0.46

0.71

0.39

4.90 ↑↑↑ ***

0.95

0.63

Nox4

2 ± 1

5 ± 3

3.26

0.66

1.28

0.90

1.76

0.43

P2rx7

190 ± 47

217 ± 30

1.31

0.86

1.78 ↑ **

0.87

1.51

1.15

P2ry2

71 ± 14

57 ± 16

4.22 ↑↑↑ ***

1.12

2.08

1.35

2.57 ↑↑

1.30

P2ry12

449 ± 52

132 ± 60

0.35 ↓↓ *

0.87

1.82 ↑↑↑ ***

0.39 ↓↓

0.95

1.53 ↑ *

Trem2

6515 ± 982

204 ± 11

0.04 ↓↓↓

0.12 ↓↓↓

0.48 ↓↓↓ ***

1.09

1.25 ↑ ***

0.79

  1. Treatments, data presentation, and analysis were as in Table 3