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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Prophylactic inhibition of neutrophil elastase prevents the development of chronic neuropathic pain in osteoarthritic mice

Fig. 3

Time course of joint mechanosensitivity induced by intra-articular (i.artic.) injection of MIA (0.3 mg/10 μl on day 0) and the effect of neutrophil elastase inhibition with sivelestat (50 mg/kg i.p., administered 10 min before and 240 min after MIA injection on day 0 and once on days 1 to 3) or serpinA1 (10 μg i.p., administered 15 min before and 12 h after MIA injection). MIA injection produced a significant decrease in tolerance to tactile stimulation throughout the 14-day time course which was inhibited by early treatment with sivelestat (P < 0.0001, two-way ANOVA) and serpinA1 (P < 0.0001, two-way ANOVA) (n = 8–9 per time point). ****P < 0.0001 as compared with baseline, one-way ANOVA

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Journal of Neuroinflammation

ISSN: 1742-2094