Fig. 7

Involvement of PAR2 in MIA-induced saphenous nerve demyelination. Upper panels show representative electron micrographs and lower panels show assessment of myelin thickness of neurons from mouse saphenous nerves 14 days after intra-articular injection of MIA or saline. Separate cohorts of wild-type (a) and PAR2 knockout (b) mice were injected with MIA (0.3 mg/10 μl) or saline (10 μl) on day 0. MIA caused significant demyelination (increased G-ratio) of the saphenous nerves of wild-type mice (a) but not of PAR2 knockout mice (b) (n = 5–10 per group), **P < 0.01, Student’s unpaired t test