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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Brain ureido degenerative protein modifications are associated with neuroinflammation and proteinopathy in Alzheimer’s disease with cerebrovascular disease

Fig. 2

Citrullination and neuroinflammation in the brain proteome of AD + CVD. a MS precursor ion intensity of the neuroinflammatory marker complement-5 core member of the membrane attack response. This marker was only identified in soluble form in the brain proteomes of AD + CVD, and it was the unique neuroinflammatory marker identified in association with the observed aggregation pattern of Cit residues. b Heatmap showing the levels of the top five most intense Cit amino acid triplets in the brain proteome of AD + CVD and age-matched controls. The small residue alanine (Ala) and the aromatic residues proline (Pro) and histidine (His) are commonly found at the flanks of Cit residues in the most abundant citrullinated peptides of the brain proteome. The column of the amino acid triplets in green color indicates the common top five amino acids and in black color, the uncommon amino acids

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