Brain ureido degenerative protein modifications are associated with neuroinflammation and proteinopathy in Alzheimer’s disease with cerebrovascular disease

Gallart-Palau, Xavier; Serra, Aida; Lee, Benjamin Sian Teck; Guo, Xue; Sze, Siu Kwan

doi:10.1186/s12974-017-0946-y

Journal of Neuroinflammation

Table 2 List of proinflammatory and immunogenic proteins that contain exclusive Cit residues in the soluble brain proteome of AD + CVD. The proteins listed in this table have been previously implicated in inflammatory and autoimmune processes (reference(s) column)

From: Brain ureido degenerative protein modifications are associated with neuroinflammation and proteinopathy in Alzheimer’s disease with cerebrovascular disease

Gene	Protein	Reference(s)	Peptide(s)	Protein residue(s)	Location	Stoicho-metry^a
CNP	2′ 3′-cyclic-nucleotide 3′-phosp.	Birnbaum et al. 1996 [61]	ELR^bQFVPGDEPR	224	Helix (223–226)	100
GFAP	Glial fibrillary acidic protein	Sasaki et al. 2014 [62]	SNLQIR^bETSLDTK	390	Tail (378–432)	100
INA	Alpha-internexin	Lu et al. 2010 [63]	RRPPASDGLDLSQAAAR^bTNEYK	83	Head (1–87)	56
INA	Alpha-internexin	Lu et al. 2010 [63]	KVFGDGSR^bLSAR	28	Head (1–87)	100
HK1	Hexokinase-1	Norman et al. 2015 [64]	ITPELLTR^bGK	331	N/A	100
HK1	Hexokinase-1	Norman et al. 2015 [64]	NGLSR^bDFNPTATVK	53	Turn (53–55)	100
NEFL	Neurofilament light polypeptide	Jain et al. 2009 [65]	YVETPR^bVHISS	23	Head (2–92)	100
ADD1	Adducin 1 (Alpha)	Rötzer et al. 2014 [66]	EDGHR^bTSTSAVPNLFVPLNTNPK	479	–	67
RTN3	Reticulon-3	Chiurchiù et al. 2014 [67]	TQIDHYVGIAR^bDQTK	1009	–	100
AK1	Adenylate kinase isoenzyme 1	Tüzün et al. 2007 [68]	YGYTHLSTGDLLR^bSEVSSGSAR	44	Helix (39–48)	100
TAGL3	Transgelin-3	Na et al. 2015 [69]	R^bGFSEEQLR	160	–	100
SYT7	Synaptotagmin-7	Chakrabarti et al. 2003 [70]	YKNSLETVGTPDSGR^bGR	63	–	100
STMN1	Stathmin	Bsibsi et al. 2010 [71]	R^bASGQAFELILSPR	14	–	71
P2RX7	P2X purinoceptor 7	Lister et al. 2007 [52]	LPLALHDTPPIPGQPEEIQLLR^bK	463	–	57
HSP90AA1	Heat shock protein HSP 90-alpha	Tukaj et al. 2016 [72]	GVVDSEDLPLNISR^bEMLQQSK	400	–	40
NEUM	Neuromodulin	Hung et al. 2016 [73]	IQASFR^bGHITR	43	–	100
MBP	Myelin basic protein	Zierath et al. 2015 [74]	FGYGGR^bASDYK	64	–	45
			SHGR^bTQDENPVVHFF	213^c	EAE (179–222)	41
			HGFLPR^bHRDTGILDSIGR	165	–	32
			FFGGDR^bGAPKR	183^c	EAE (179–222)	75
			YLATASTMDHAR^bHG	159	–	58
			FSWGAEGQRPGFGYGGR^bASDYKSAHK	264	–	45
CTTN	Src substrate cortactin	Labrador-Horrillo et al. 2014 [75]	HCSQVDSVR^bGFGGK	119	–	100

^bIndicates the citrulline residues in the identified peptides
^cIndicates the MBP citrulline residues in mice that were identified in the protein homolog region that induces experimental autoimmune encephalomyelitis (EAE)
^aIndicates the stoichiometric ratio (percentage of occurrence) of Cit from the total peptides identified that contain the Arg site in the protein (unmodified + modified)

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ISSN: 1742-2094

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