Fig. 5

TMP significantly attenuated CCI-induced neuron cell activation and IL-1β production in spinal cords. a Single administration of TMP significantly inhibited the cleavage of IL-1β. TMP (30 mg/kg, i.p.) was administered on the 14th day after CCI operation. b Single administration of TMP inhibited CCI-induced phosphorylation of protein kinase C (PKC) γ and N-methyl-D-aspartate receptor (NR) 1. TMP (30 mg/kg, i.p.) was administered on the 14th day after CCI operation. The western blot samples (n = 6) were collected at 4 h after TMP administration. A significant difference was at *P < 0.05, **P < 0.01 vs. control; ^# P < 0.05, ^## P < 0.01 vs. CCI group