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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Selective suppression of the JNK-MMP2/9 signal pathway by tetramethylpyrazine attenuates neuropathic pain in rats

Fig. 6

TMP attenuated the level of pTAK1, which could be mimicked by TAK1 and JNK inhibitors. a Single administration of TMP (30 kg/mg, i.p) after CCI operation 14 days significantly suppressed CCI-induced TAK1 phosphorylation in the spinal cord. Consecutive administration of TMP (30 kg/mg, i.p) for 5 days from 14 days after CCI operation significantly attenuated CCI-induced TAK1 phosphorylation. The western blot samples (n = 6) were collected as described above. b Administration of TAK1 inhibitor (5 μg/10 μl, i.t.) and JNK inhibitor (5 μg/10 μl, i.t.) significantly inhibited CCI-induced MMP-2 and MMP-9. c Administration of JNK inhibitor and TAK1 inhibitor inhibited CCI-induced mechanical allodynia. A significant difference was at *P < 0.05, **P < 0.01 vs. control; # P < 0.05, ## P < 0.01 vs. CCI group

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