Fig. 7

TMP inhibits IL-1β-induced TAK-1, JNK phosphorylation, and GFAP and MMP-2/9 activation of astrocytes in mice. a TMP (30 mg/kg, i.p.), the TAK1 inhibitor 5Z-7-oxozeaenol (5 μg/10 ul, i.t.) and the JNK inhibitor SP600125 (5 μg/10 ul, i.t.) attenuated the hyperalgia induced by intrathecal injection of 10 μl of IL-1β (20 ng/ml). b TMP, 5Z-7-oxozeaenol and SP600125 suppressed the higher expression levels of GFAP after the injection of IL-1β. c TMP, 5Z-7-oxozeaenol, and SP600125 inhibited the activation of MMP-2 and MMP-9 after intrathecal injection of 10 μl of IL-1β (20 ng/ml i.t.). d TMP, 5Z-7-oxozeaenol, and SP600125 inhibited the increased phosphorylation of JNK and TAK1 induced by IL-1β. A significant difference was at *P < 0.05, **P < 0.01 vs. control; ^# P < 0.05, ^## P < 0.01 vs. IL-1β group