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Table 1 Baseline characteristics of the patient groups

From: Cerebrospinal fluid CXCL13 as a diagnostic marker of neuroborreliosis in children: a retrospective case-control study

 

AI

Pleo.

n (M/F)

Agea (years)

CSF cell counta (cells/ul)

Mononuclear cellsa (%)

Symptoms durationa (days)

Facial palsyb

Headacheb

Cranial nerv palsyb

Negative serologyb

Definite LNB

+

+

53 (30/23)

7.7 (2.2–15.5)

154.0 (8–1289)

98.5 (74–100)

9.0 (0–109)

35 (66)

15 (28)

1 (2)

5 (9)

Possible LNB

  

41 (17/24)

8.3 (1.8–15.7)

47.0 (3–999)

96.4 (10–100)

4.0 (0–128)

8 (20)

20 (49)

4 (10)

25 (61)

 AI neg.

+

27 (10/17)

8.8 (1.8–15.7)

76.0 (7–999)

97.7 (10–100)

3.0 (0–14)

5 (19)

13 (48)

4 (15)

13 (48)

 AI nd.

nd

+

13 (6/7)

6.2 (2.7–15.5)

31.0 (16–448)

96.0 (59–100)

6.0 (1–128)

2 (15)

7 (54)

0 (0)

12 (92)

 AI pos.

+

1 (1/0)

7.9

3.0

nd

14.0

1 (100)

0 (0)

0 (0)

0 (0)

Non-LNB

  

91 (49/42)

10.0 (1.1–17.7)

2.0 (0–1174)

75.7 (18–99)

3.0 (0–166)

23 (25)

33 (36)

6 (7)

69 (76)

 VZV

−/+

4 (3/1)

7.8 (1.8–17.7)

7.5 (0–579)

95.9 (92–99)

5.5 (0–10)

2 (50)

1 (25)

0 (0)

4 (100)

 Enterovirus

−/+

20 (10/10)

7.2 (1.1–15.2)

194.0 (0–1174)

76.5 (18–98)

1.0 (0–21)

0 (0)

13 (65)

0 (0)

17 (85)

 TBEV

+

5 (4/1)

10.8 (5.6–15)

80.0 (43–104)

71.6 (28–90)

3.0 (2–5)

0 (0)

5 (100)

0 (0)

3 (60)

 Inflammatory

8 (1/7)

10.4 (5–15.5)

2.0 (0–5)

nd

2.5 (1–31)

0 (0)

0 (0)

0 (0)

5 (63)

 Facial palsy

19 (11/8)

11.7 (1.5–15.7)

2.0 (0–5)

nd

3.0 (0–38)

19 (100)

0 (0)

0 (0)

14 (74)

 Headache

11 (3/8)

13.8 (6.1–16.9)

0.0 (0–3)

nd

31.0 (0–166)

0 (0)

11 (100)

0 (0)

7 (64)

 Others

24 (17/7)

6.6 (2.1–17.4)

1.0 (0–5)

nd

4.0 (0–162)

2 (8)

3 (13)

6 (25)

19 (79)

Total

  

185 (96/89)

8.2 (1.1–17.7)

34.0 (0–1289)

97.1 (10–100)

5.0 (0–166)

66 (36)

68 (37)

11 (6)

99 (54)

  1. Symptoms duration is until the diagnostic lumbar puncture
  2. Negative serology means negative Borrelien-specific IgM and IgG screening test in blood at initial work-up
  3. The “Inflammatory” group included three Guillain-Barré syndrome, three retrobulbar optic neuritis, one acute disseminated encephalomyelitis (ADEM), and one parainfectious brainstem encephalitis
  4. LNB Lyme neuroborreliosis, AI antibody index, Pleo. pleocytosis (>5 cells/μl in CSF), n numbers, M/F male/female, neg. negative, nd not determined, pos. positive, VZV varicella-zoster virus, TBEV tick-borne encephalitis virus
  5. aData are presented as median (range)
  6. bData are presented as number (%)