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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Effects of surgery and propofol-remifentanil total intravenous anesthesia on cerebrospinal fluid biomarkers of inflammation, Alzheimer’s disease, and neuronal injury in humans: a cohort study

Fig. 1

Dynamic changes in significant biomarkers. Biomarkers that had significant dynamic changes over time, when adjusted for multiple comparisons (see also Table 1 and Additional file 1: Table S1). ah Each panel shows data for all individual subjects, and the average effect from a linear mixed effects model. For PIGF, MIP-1, and VEGF-A, a comparison of models favored a spline function to model time. For these biomarkers, β1 (linear parameter) and β2 (spline parameter) coefficients are presented. For the other biomarkers, time was modeled with a single parameter. P values are corrected for multiple comparisons (see Table 1 for uncorrected data)

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