|
Group
|
Incidence/total (%)
|
Number of mice dead
|
Disease onset (days)a
|
Clinical scores (mean ± SE)
|
|---|
|
pid-20b
|
pid-40c
|
|---|
|
EAE
|
11/11 (100%)
|
0
|
10.9 ± 0.71
|
2.27 ± 0.12
|
2.14 ± 0.10
|
|
EAE/glib-pid-12
|
10/10 (100%)
|
1
|
10.7 ± 0.27
|
1.20 ± 0.32
|
0.78 ± 0.28
|
|
EAE/glib-pid-24
|
12/12 (100%)
|
0
|
11.7 ± 0.80
|
2.21 ± 0.17
|
1.17 ± 0.24
|
-
aDisease onset is defined as the first day of a clinical score of one or more. There was no statistically significant difference in day of disease onset between groups
-
bThe Kruskall-Wallis test indicated a significant difference between groups (P = 0.0257) on pid-20, with Dunn’s post hoc comparisons indicating that the EAE group was statistically different compared to the EAE/glib-pid-12 group (P < 0.05); the EAE and EAE/glib-pid-24 groups were not statistically different
-
cThe Kruskall-Wallis test indicated a significant difference between groups (P = 0.0010) on pid-40, with Dunn’s post hoc comparisons indicating that the EAE group was statistically different compared to both the EAE/glib-pid-12 (P < 0.01) and the EAE/glib-pid-24 (P < 0.05) groups; the EAE/glib-pid-12 and EAE/glib-pid-24 groups were not statistically different
