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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Impact of combined sodium chloride and saturated long-chain fatty acid challenge on the differentiation of T helper cells in neuroinflammation

Fig. 1

Combined NaCl + LA challenge promotes polarization of naïve T cells towards Th17 cells in vitro. a Addition of either 40 mM NaCl, 250 μM LA, or both to CD4+ T cell differentiation culture under Th1-polarizing conditions (data pooled from five independent experiments, *p < 0.05, ***p < 0.001). b IFNγ production of Th1 cells treated with either 40 mM NaCl, 250 μM LA, or both (data pooled from four to five independent experiments). c Addition of either 40 mM NaCl, 250 μM LA, or both to CD4+ T cell differentiation culture under Th17-polarizing conditions (data pooled from three independent experiments, *p < 0.05, **p < 0.01, ***p < 0.001). d IL-17 production of Th17 cells treated with either 40 mM NaCl, 250 μM LA, or both (three to four independent experiments are shown). e Addition of either 40 mM NaCl, 250 μM LA, or both to CD4+ T cell differentiation culture under Th2-polarizing conditions (data pooled from three independent experiments, *p < 0.05, **p < 0.01, ***p < 0.001)

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