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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Primary cilia modulate TLR4-mediated inflammatory responses in hippocampal neurons

Fig. 1

Primary ciliary length decreased in hippocampal pyramidal neurons after LPS treatment in wild type mice, but increased in TLR4−/− mice. The brains from wild type (a) and TLR4−/− mice (TLR4 K.O (c)) were stained for ACIII (red) and DAPI (blue) after intracerebroventricular injection of LPS. Panels show representative images from four to five mice before (control) and 1 (LPS-1D) and 3 (LPS-3D) days after LPS treatment. ACIII-reactive ciliary length (b, d) in the CA1 region was measured at the same time points. Ciliary length was significantly shorter in wild type mice, but longer in TLR4−/− mice, after LPS treatment. The data are presented as mean ± SEM. **p < 0.01, ***p < 0.001. Scale bar = 20 μm in a and c; 10 μm in the corresponding inset images

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