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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Fluoxetine-enhanced autophagy ameliorates early brain injury via inhibition of NLRP3 inflammasome activation following subarachnoid hemorrhage in rats

Fig. 2

Double staining for PI with NeuN (neuron marker), Iba-1(microglia marker), GFAP(astrocyte marker), and caspase-1, and ultrastructural changes of necrotic cells. a Double staining for PI with NeuN (neuron marker), Iba-1(microglia marker), and GFAP(astrocyte marker). Scale bar = 50 μm. b Double staining for PI with caspase-1 in the ipsilateral cortex at 24 h after SAH. Scale bar = 50 μm. c Ultrastructural changes of necrotic cells at 24 h after SAH. Neurons in the left panel appeared normal with nuclei, mitochondria, and cytomembranes. Neurons in the right panel showed fragmented nuclei (black asterisk), swollen mitochondria (red asterisk), disrupted cytomembranes (white arrow), damaged organelles (white arrow), and double-membrane autophagosomes (red arrow). Scale bar = 2 μm

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Journal of Neuroinflammation

ISSN: 1742-2094