Skip to main content
Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Fluoxetine-enhanced autophagy ameliorates early brain injury via inhibition of NLRP3 inflammasome activation following subarachnoid hemorrhage in rats

Fig. 4

Fluoxetine reduced expression of NLRP3, caspase-1 p20, IL-1ß, and IL-18, decreased the numbers of necrotic cells and brain edema, and improved the neurological scores. a Representative Western blots and densitometric analyses of levels of NLRP3, caspase-1 p20, IL-1ß, and IL-18. The bar represents the mean ± SD. **P < 0.01 vs sham. # P < 0.05 vs vehicle control, ## P < 0.01 vs vehicle control. b Representative photomicrographs of PI-positive neural cells in different groups at 24 h after SAH (n = 3/group). Fluorescence colors: DAPI: blue and PI: red. Scale bar = 100 μm. c The quantification of the PI-positive neural cells. The quantification of the PI-positive neural cells expressed as positive cells per square millimeter. The bar represents the mean ± SD. **P < 0.01 vs sham, ## P < 0.01 vs vehicle control. d Quantification of brain water content (n = 6). The bars represent the mean ± SD. **P < 0.01 vs sham control, ## P < 0.01 vs vehicle control. e Quantification of neurological scores (n=18). The bars represent the mean with interquartile range. *P < 0.05 vs sham control, # P < 0.05 vs vehicle control

Back to article page