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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Activation of dorsal horn cannabinoid CB2 receptor suppresses the expression of P2Y12 and P2Y13 receptors in neuropathic pain rats

Fig. 1

Intrathecal injection of AM1241 attenuated CCI-induced hyperalgesia. Pain sensitivity was determined by measuring TWL on the day before CCI and on days 1, 3, 5, 7, 10, and 14 after nerve injury. After nerve injury, the TWL in the vehicle-treated CCI group (0.005% DMSO) was significantly lower than that in the sham group (*P < 0.05). No significant difference was identified between the vehicle-treated CCI group and 1pM AM1241-treated CCI group. At 1, 3, 5, 7, 10, and 14 days after nerve injury, the TWL in the 10- and 100pM AM1241-treated CCI rats were significantly higher than that in the vehicle-treated CCI group (10pM: + P < 0.05; 100pM: + P < 0.05). All values represent mean ± standard deviation (n = 8). *P < 0.05 compared with the sham group; + P < 0.05 compared with the vehicle-treated CCI group

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