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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Lentivirus-mediated interleukin-1β (IL-1β) knock-down in the hippocampus alleviates lipopolysaccharide (LPS)-induced memory deficits and anxiety- and depression-like behaviors in mice

Fig. 3

The influence of pretreatment with IL-1β shRNA lentivirus on the levels of oxidative or anti-oxidative parameters induced by LPS in the hippocampus of mice. a The upregulation of MDA in the hippocampus induced by LPS was significantly alleviated by IL-1β knock-down in the mice. b The downregulation of SOD in the hippocampus induced by LPS was significantly alleviated by IL-1β knock-down in the mice. c, e Representative immunoblots of Nrf2 and HO1 detected by western blotting with tissues from the hippocampus, and the rest of the panels are quantifications of the immunoblot bands of Nrf2 (d) and HO1 (f). The decrease in Nrf2 and HO1 in the hippocampus induced by LPS was significantly alleviated by IL-1β knock-down. The data are expressed as the mean ± S.E.M (n = 3 per group for western blotting and n = 6 per group for ELISA). **p < 0.01 compared with the NS shRNA plus saline group; #p < 0.05 or ##p < 0.01 compared with the NS shRNA + LPS group

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