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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: The contribution of the acute phase response to the pathogenesis of relapse in chronic-relapsing experimental autoimmune encephalitis models of multiple sclerosis

Fig. 1

Peripheral production of chemokines and APPs precedes clinical signs in EAE. Quantitative RT-PCR on hepatic tissue collected from EAE animals (n = 6) at days 10, 14, 17 and 28 revealed a significantly elevated mRNA expression of CXCL-10 (a), SAP (b), SAA1 (c) and SAA2 (d) at day 10, before the onset of clinical signs when compared to CFA mice at the same time point (p < 0.05). CXCL-10, SAA1 and SAA2 declined to control levels when the animals were symptomatic (days 14 and 17) and in remission (day 28). SAP levels persisted at day 14 and declined dramatically by day 17. The dotted line indicates the basal level of each marker in naive animals. *p < 0.05

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