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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: The contribution of the acute phase response to the pathogenesis of relapse in chronic-relapsing experimental autoimmune encephalitis models of multiple sclerosis

Fig. 2

Production of chemokines and APPs in the CNS is highest during the acute phase of EAE. Quantitative RT-PCR on brain tissue collected from EAE and CFA animals (n = 6) at days 10, 14, 17 and 28 revealed a significantly elevated mRNA expression of IL-1β (a), IL-17 (b), CCL5 (c) CXCL-10 (d) and CCL2 (e) at day 14, during the acute phase of the disease when compared to CFA mice (p < 0.05) and declined by day 17, with the exception of IL-1β and CCL5 which returned to control levels after day 17. The dotted line indicates the basal level of each marker in naive animals. *p < 0.05

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Journal of Neuroinflammation

ISSN: 1742-2094