Fig. 3

Peripheral LPS administration in EAE exacerbates the relapse phase. EAE mice injected with LPS (n = 5) scored more than EAE mice injected with saline (n = 5) (a) There was a delay of 5 days from the administration of LPS until clinical signs were significantly greater than saline-treated mice. LPS-treated mice performed significantly worse in behavioural tests and spent less time on the inverted screen (b (i)) with a reduction in the time of the first foot-fall (b (ii)), which achieved significance on days 37 and 38