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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: The contribution of the acute phase response to the pathogenesis of relapse in chronic-relapsing experimental autoimmune encephalitis models of multiple sclerosis

Fig. 4

Hepatic mRNA production of acute phase proteins and chemokines increases 8 days after LPS challenge in CR-EAE animals but not in CFA mice. Hepatic mRNA production of SAA1 (a), SAA2 (b), SAP (c) and CXCL-1 (d) was significantly higher in LPS-treated EAE mice (n = 5) when compared to that in saline-treated EAE mice (n = 5) (p < 0.05). No significant differences in CXCL-10 (e) and CCL5 (f) were found between the LPS-challenged mice and saline-treated animals. LPS administration in control CFA mice (n = 5) had no effect on the production of these acute phase proteins and chemokines when compared to saline-treated CFA mice (n = 4)

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Journal of Neuroinflammation

ISSN: 1742-2094