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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: The contribution of the acute phase response to the pathogenesis of relapse in chronic-relapsing experimental autoimmune encephalitis models of multiple sclerosis

Fig. 5

In EAE acute phase, protein and chemokine expression increases in the brain 8 days after LPS challenge without having an effect in CFA mice. mRNA production of CCL5 (a), SAA1 (b) and SAA2 (c) in the brain was higher in LPS-treated EAE mice (n = 5) when compared to that in saline-treated EAE mice (n = 5) (p < 0.05). LPS administration in control CFA mice (n = 5) had no effect on the production of these acute phase proteins and expressed levels that were comparable to saline-treated CFA mice (n = 4). There were no significant changes in the levels of SAP (d), CXCL-10 (e), IL-1β (f), IL-17 (g) and CXCL-1 (h)

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Journal of Neuroinflammation

ISSN: 1742-2094