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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: The contribution of the acute phase response to the pathogenesis of relapse in chronic-relapsing experimental autoimmune encephalitis models of multiple sclerosis

Fig. 6

CXCL-1 increases the lesion activity in the fEAE model. At 7 days, animals that received a peripheral injection of 1 μg CXCL-1 iv displayed more (a) Iba1 immunoreactive microglia/macrophages (p < 0.05) and b more T cells (OX-22-positive) were present within the lesions than in those animals that received saline vehicle. Photomicrographs of iba1 (Aii and Aiii) and OX22 (Bii and Biii) staining in the lesions of the control and CXCL-1-treated animals respectively. Scale bar = 20 μm

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