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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Withania somnifera as a potential candidate to ameliorate high fat diet-induced anxiety and neuroinflammation

Fig. 5

ASH modulated NF-κB pathway and prevented apoptosis. a, c Representative Western blot analysis for markers of NF-κB pathway in the hippocampus and PC regions of brain among the LFD, HFD, and HFDE animals. Histograms represent percent change in intensity taking value in LFD rats as 100%. b, d Representative Western blot analysis for apoptotic markers AP-1 and Bcl-xL in the hippocampus and PC regions of brain among the LFD, HFD, and HFDE rats. Histograms represent percent change in intensity taking value in LFD rats as 100%. e Histograms representing fold change in mRNA expression of markers of NF-κB pathway and apoptotic markers in the hippocampus and PC regions of rat brain among the four groups of animals (n = 3–4 each group). Values are expressed as mean ± SEM. * p ≤ 0.05 LFD versus HFD, LFDE, and HFDE rats, # p ≤ 0.05 HFD versus HFDE rats, $ p ≤ 0.05 HFD versus LFDE rats, @ p ≤ 0.05 LFDE versus HFDE rats, Holm–Sidak method after one-way ANOVA

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