Fig. 1From: Erythropoietin reduces experimental autoimmune encephalomyelitis severity via neuroprotective mechanismsEAE disease progression and weight loss in wt, tg6 (rhEpo expression in CNS and periphery), and tg21 mice (rhEpo expression in CNS only). a Quantitative RT-PCR analysis of Epo mRNA expression in spinal cord at different EAE stages in wt mice. n = 3, Student’s t tests versus naïve. b EAE progression monitored in mice immunized with MOG using a standard method that scores the degree of paralysis on a 1 to 5 scale. c Weight fluctuations of the same group of mice during disease. Start weight was set to 100%. In all strains, the onset of weight loss correlates well with the onset of disability whereas the partial recovery from disability coincides with a gain in weight. d Mean accumulative clinical score. e Hematocrit measurements at the end of experiment. Combined results of six independent experiments are shown. n = 39 tg21, 25 tg6, and 75 wt (b, c) ANOVA, *significant difference wt versus tg21 (p < 0.05 or more), + significant difference wt versus tg6 (p < 0.05 or more), # significant difference tg21 versus tg6 (p < 0.05 or more); (d, e) t test versus wt *p < 0.05, ***p < 0.001Back to article page