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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Erythropoietin reduces experimental autoimmune encephalomyelitis severity via neuroprotective mechanisms

Fig. 1

EAE disease progression and weight loss in wt, tg6 (rhEpo expression in CNS and periphery), and tg21 mice (rhEpo expression in CNS only). a Quantitative RT-PCR analysis of Epo mRNA expression in spinal cord at different EAE stages in wt mice. n = 3, Student’s t tests versus naïve. b EAE progression monitored in mice immunized with MOG using a standard method that scores the degree of paralysis on a 1 to 5 scale. c Weight fluctuations of the same group of mice during disease. Start weight was set to 100%. In all strains, the onset of weight loss correlates well with the onset of disability whereas the partial recovery from disability coincides with a gain in weight. d Mean accumulative clinical score. e Hematocrit measurements at the end of experiment. Combined results of six independent experiments are shown. n = 39 tg21, 25 tg6, and 75 wt (b, c) ANOVA, *significant difference wt versus tg21 (p < 0.05 or more), + significant difference wt versus tg6 (p < 0.05 or more), # significant difference tg21 versus tg6 (p < 0.05 or more); (d, e) t test versus wt *p < 0.05, ***p < 0.001

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