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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Elevated microRNA-129-5p level ameliorates neuroinflammation and blood-spinal cord barrier damage after ischemia-reperfusion by inhibiting HMGB1 and the TLR3-cytokine pathway

Fig. 3

Confirmation of a direct interaction between miR-129-5p and HMGB1. a Schematic representation of the predicted interaction between miR-129-5p and HMGB1 based on TargetScan. b Binding site of miR-129-5p in the WT and MT 3′UTR of HMGB1. c Dual-luciferase reporter gene assay. Luciferase activity was measured after 48 h of co-transfection of HEK-293 cells with the miR-129-5p mimic and the WT or MT reporter vector. Compared to the control, miR-129-5p significantly decreased the luciferase activity of the WT vector but not that of the MT vector. Data are expressed as the mean ± SD. *P < 0.05 versus the control miR

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Journal of Neuroinflammation

ISSN: 1742-2094