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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Elevated microRNA-129-5p level ameliorates neuroinflammation and blood-spinal cord barrier damage after ischemia-reperfusion by inhibiting HMGB1 and the TLR3-cytokine pathway

Fig. 4

Double immunofluorescence of HMGB1 with markers of major cell types in the spinal cord after IR. a Representative fluorescence images of the distribution of HMGB1 (red) in neurons (NeuN; green), microglia (Iba1; green) and astrocytes (GFAP; green) in the spinal cords at 12 and 48 h after IR. Arrows indicate co-localization. Scale bars = 50 μm. b Quantification of HMGB1 signals was performed based on the average of three independent images. c Quantification of HMGB1-positive neurons and microglia in the spinal cords at 12 h and 48 h after IR. Data are expressed as the mean ± SD. *P < 0.05 versus the Sham group

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Journal of Neuroinflammation

ISSN: 1742-2094