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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Acute in utero exposure to lipopolysaccharide induces inflammation in the pre- and postnatal brain and alters the glial cytoarchitecture in the developing amygdala

Fig. 5

MIA induced cytoarchitectural changes in the postnatal amygdala. Nissl staining was carried out to examine the structural alterations in the postnatal amygdala after MIA (a). In addition, stereological analyses were carried out to measure volume differences and cell counts in the developing amygdala in LPS and saline-treated control pups (b-e). Analyses revealed that the amygdala at P14 is most vulnerable to neuron and volume loss, in particular the central nuclei (b-e). A decrease in volume and also cell number was observed in the Ce at P14 (c, e). However, P7 and P40 remained unaffected with respect to LPS or saline treatment (b-e). Comparisons were carried out between each treatment with respect to treatment using the Student t test. Significant difference denoted as *p < 0.05, **p < 0.01, and ***p < 0.001

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