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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Lidocaine alleviates morphine tolerance via AMPK-SOCS3-dependent neuroinflammation suppression in the spinal cord

Fig. 4

Distribution and cellular localization of SOCS3 in the dorsal horn of the spinal cord. a Confocal microscopy study for SOCS3 (green) and its co-localization with neurons (NeuN, red) in the dorsal horn. b Confocal microscopy study for SOCS3 (green) and its co-localization with microglia (Iba1, red) in the dorsal horn. c Confocal microscopy study for SOCS3 (green) and its co-localization with astrocytes (GFAP, red) in the dorsal horn. Lidocaine (100, 200, and 400 μg/10 μL, i.t.) was given once daily for 7 days. Spinal samples were collected after the last administration of lidocaine

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