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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Human antibodies against the myelin oligodendrocyte glycoprotein can cause complement-dependent demyelination

Fig. 2

a Myelin staining with serum from human samples and monoclonal 8-18-C5 on human, mouse, or rat cerebellum. White matter tracts and folia were clearly stained with MOG antibody-positive serum samples and 8-18-C5 but not in MOG antibody-negative control samples. Sections were magnified at ×20 (mouse/rat tissue) and at ×10 (human tissue). b Serum samples reactive to human and mouse MOG bind to both human and mouse cerebellum sections. Pre-adsorbed samples show a significant reduction in MOG-specific myelin staining. Sections were magnified at ×2.5 (human tissue) and at ×20 (mouse tissue). Inlays show higher magnification (10×) of human white matter tracts

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Journal of Neuroinflammation

ISSN: 1742-2094