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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Human antibodies against the myelin oligodendrocyte glycoprotein can cause complement-dependent demyelination

Fig. 5

Spinal cord sections of MBP-T cell EAE animals co-injected with patient antibodies. Patient IgG was reactive to either human, rat, and mouse MOG (h/r/mMOG pos., MOG 7); human and mouse MOG (h/mMOG pos., MOG 6); or negative to human MOG (hMOG neg.) tested by CBA KL, Kluver-Barrera (myelin); MOG, myelin oligodendrocyte glycoprotein; ED1, macrophages; CD3, T cells; C9, complement. Spinal cord slices were digitally magnified at 3.8× and highlighted sections at ×20

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Journal of Neuroinflammation

ISSN: 1742-2094