TY - JOUR AU - Shenoy, P. A. AU - Kuo, A. AU - Vetter, I. AU - Smith, M. T. PY - 2016 DA - 2016// TI - The Walker 256 breast cancer cell-induced bone pain model in rats JO - Front Pharmacol VL - 7 UR - https://doi.org/10.3389/fphar.2016.00286 DO - 10.3389/fphar.2016.00286 ID - Shenoy2016 ER - TY - JOUR AU - Kane, C. M. AU - Hoskin, P. AU - Bennett, M. I. PY - 2015 DA - 2015// TI - Cancer induced bone pain JO - BMJ VL - 350 UR - https://doi.org/10.1136/bmj.h315 DO - 10.1136/bmj.h315 ID - Kane2015 ER - TY - JOUR AU - Mantyh, P. PY - 2013 DA - 2013// TI - Bone cancer pain: causes, consequences, and therapeutic opportunities JO - Pain VL - 154 UR - https://doi.org/10.1016/j.pain.2013.07.044 DO - 10.1016/j.pain.2013.07.044 ID - Mantyh2013 ER - TY - JOUR AU - Portenoy, R. K. PY - 2011 DA - 2011// TI - Treatment of cancer pain JO - Lancet VL - 377 UR - https://doi.org/10.1016/S0140-6736(11)60236-5 DO - 10.1016/S0140-6736(11)60236-5 ID - Portenoy2011 ER - TY - JOUR AU - Li, X. J. AU - Jiang, Z. Z. AU - Zhang, L. Y. PY - 2014 DA - 2014// TI - Triptolide: progress on research in pharmacodynamics and toxicology JO - J Ethnopharmacol VL - 155 UR - https://doi.org/10.1016/j.jep.2014.06.006 DO - 10.1016/j.jep.2014.06.006 ID - Li2014 ER - TY - JOUR AU - Meng, C. AU - Zhu, H. AU - Song, H. AU - Wang, Z. AU - Huang, G. AU - Li, D. AU - Ma, Z. AU - Ma, J. AU - Qin, Q. AU - Sun, X. AU - Ma, J. PY - 2014 DA - 2014// TI - Targets and molecular mechanisms of triptolide in cancer therapy JO - Chin J Cancer Res VL - 26 ID - Meng2014 ER - TY - JOUR AU - Zhao, X. AU - Zhang, Q. AU - Chen, L. PY - 2016 DA - 2016// TI - Triptolide induces the cell apoptosis of osteosarcoma cells through the TRAIL pathway JO - Oncol Rep VL - 36 UR - https://doi.org/10.3892/or.2016.4957 DO - 10.3892/or.2016.4957 ID - Zhao2016 ER - TY - JOUR AU - Jiang, C. AU - Fang, X. AU - Zhang, H. AU - Wang, X. AU - Li, M. AU - Jiang, W. AU - Tian, F. AU - Zhu, L. AU - Bian, Z. PY - 2017 DA - 2017// TI - Triptolide inhibits the growth of osteosarcoma by regulating microRNA-181a via targeting PTEN gene in vivo and vitro JO - Tumour Biol VL - 39 ID - Jiang2017 ER - TY - JOUR AU - Mujumdar, N. AU - Mackenzie, T. N. AU - Dudeja, V. AU - Chugh, R. AU - Antonoff, M. B. AU - Borja-Cacho, D. AU - Sangwan, V. AU - Dawra, R. AU - Vickers, S. M. AU - Saluja, A. K. PY - 2010 DA - 2010// TI - Triptolide induces cell death in pancreatic cancer cells by apoptotic and autophagic pathways JO - Gastroenterology VL - 139 UR - https://doi.org/10.1053/j.gastro.2010.04.046 DO - 10.1053/j.gastro.2010.04.046 ID - Mujumdar2010 ER - TY - JOUR AU - Manzo, S. G. AU - Zhou, Z. L. AU - Wang, Y. Q. AU - Marinello, J. AU - He, J. X. AU - Li, Y. C. AU - Ding, J. AU - Capranico, G. AU - Miao, Z. H. PY - 2012 DA - 2012// TI - Natural product triptolide mediates cancer cell death by triggering CDK7-dependent degradation of RNA polymerase II JO - Cancer Res VL - 72 UR - https://doi.org/10.1158/0008-5472.CAN-12-1006 DO - 10.1158/0008-5472.CAN-12-1006 ID - Manzo2012 ER - TY - JOUR AU - Liang, M. AU - Fu, J. PY - 2008 DA - 2008// TI - Triptolide inhibits interferon-gamma-induced programmed death-1-ligand 1 surface expression in breast cancer cells JO - Cancer Lett VL - 270 UR - https://doi.org/10.1016/j.canlet.2008.05.025 DO - 10.1016/j.canlet.2008.05.025 ID - Liang2008 ER - TY - JOUR AU - Shao, H. AU - Ma, J. AU - Guo, T. AU - Hu, R. PY - 2014 DA - 2014// TI - Triptolide induces apoptosis of breast cancer cells via a mechanism associated with the Wnt/beta-catenin signaling pathway JO - Exp Ther Med VL - 8 UR - https://doi.org/10.3892/etm.2014.1729 DO - 10.3892/etm.2014.1729 ID - Shao2014 ER - TY - JOUR AU - Carter, B. Z. AU - Mak, D. H. AU - Schober, W. D. AU - Dietrich, M. F. AU - Pinilla, C. AU - Vassilev, L. T. AU - Reed, J. C. AU - Andreeff, M. PY - 2008 DA - 2008// TI - Triptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5 JO - Blood VL - 111 UR - https://doi.org/10.1182/blood-2007-05-091504 DO - 10.1182/blood-2007-05-091504 ID - Carter2008 ER - TY - JOUR AU - Carter, B. Z. AU - Mak, D. H. AU - Shi, Y. AU - Fidler, J. M. AU - Chen, R. AU - Ling, X. AU - Plunkett, W. AU - Andreeff, M. PY - 2012 DA - 2012// TI - MRx102, a triptolide derivative, has potent antileukemic activity in vitro and in a murine model of AML JO - Leukemia VL - 26 UR - https://doi.org/10.1038/leu.2011.246 DO - 10.1038/leu.2011.246 ID - Carter2012 ER - TY - JOUR AU - Wang, W. AU - Mei, X. P. AU - Chen, L. AU - Tang, J. AU - Li, J. L. AU - SX, W. AU - LX, X. AU - Li, Y. Q. PY - 2012 DA - 2012// TI - Triptolide prevents and attenuates neuropathic pain via inhibiting central immune response JO - Pain Physician VL - 15 ID - Wang2012 ER - TY - JOUR AU - Tang, J. AU - Li, Z. H. AU - Ge, S. N. AU - Wang, W. AU - Mei, X. P. AU - Wang, W. AU - Zhang, T. AU - Xu, L. X. AU - Li, J. L. PY - 2012 DA - 2012// TI - The inhibition of spinal astrocytic JAK2-STAT3 pathway activation correlates with the analgesic effects of triptolide in the rat neuropathic pain model JO - Evid Based Complement Alternat Med VL - 2012 ID - Tang2012 ER - TY - JOUR AU - Hang, L. H. AU - Li, S. N. AU - Shao, D. H. AU - Chen, Z. AU - Chen, Y. F. AU - Shu, W. W. PY - 2014 DA - 2014// TI - Evidence for involvement of spinal RANTES in the antinociceptive effects of triptolide, a diterpene triepoxide, in a rat model of bone cancer pain JO - Basic Clin Pharmacol Toxicol VL - 115 UR - https://doi.org/10.1111/bcpt.12265 DO - 10.1111/bcpt.12265 ID - Hang2014 ER - TY - JOUR AU - Clark, A. K. AU - Old, E. A. AU - Malcangio, M. PY - 2013 DA - 2013// TI - Neuropathic pain and cytokines: current perspectives JO - J Pain Res VL - 6 ID - Clark2013 ER - TY - JOUR AU - Grace, P. M. AU - Hutchinson, M. R. AU - Maier, S. F. AU - Watkins, L. R. PY - 2014 DA - 2014// TI - Pathological pain and the neuroimmune interface JO - Nat Rev Immunol VL - 14 UR - https://doi.org/10.1038/nri3621 DO - 10.1038/nri3621 ID - Grace2014 ER - TY - JOUR AU - Geis, C. AU - Graulich, M. AU - Wissmann, A. AU - Hagenacker, T. AU - Thomale, J. AU - Sommer, C. AU - Schafers, M. PY - 2010 DA - 2010// TI - Evoked pain behavior and spinal glia activation is dependent on tumor necrosis factor receptor 1 and 2 in a mouse model of bone cancer pain JO - Neuroscience VL - 169 UR - https://doi.org/10.1016/j.neuroscience.2010.04.022 DO - 10.1016/j.neuroscience.2010.04.022 ID - Geis2010 ER - TY - JOUR AU - Ren, B. X. AU - XP, G. AU - Zheng, Y. G. AU - Liu, C. L. AU - Wang, D. AU - Sun, Y. E. AU - Ma, Z. L. PY - 2012 DA - 2012// TI - Intrathecal injection of metabotropic glutamate receptor subtype 3 and 5 agonist/antagonist attenuates bone cancer pain by inhibition of spinal astrocyte activation in a mouse model JO - Anesthesiology VL - 116 UR - https://doi.org/10.1097/ALN.0b013e31823de68d DO - 10.1097/ALN.0b013e31823de68d ID - Ren2012 ER - TY - JOUR AU - Shen, W. AU - XM, H. AU - Liu, Y. N. AU - Han, Y. AU - Chen, L. P. AU - Wang, C. C. AU - Song, C. PY - 2014 DA - 2014// TI - CXCL12 in astrocytes contributes to bone cancer pain through CXCR4-mediated neuronal sensitization and glial activation in rat spinal cord JO - J Neuroinflammation VL - 11 UR - https://doi.org/10.1186/1742-2094-11-75 DO - 10.1186/1742-2094-11-75 ID - Shen2014 ER - TY - JOUR AU - Song, H. AU - Han, Y. AU - Pan, C. AU - Deng, X. AU - Dai, W. AU - Hu, L. AU - Jiang, C. AU - Yang, Y. AU - Cheng, Z. AU - Li, F. PY - 2015 DA - 2015// TI - Activation of adenosine monophosphate-activated protein kinase suppresses neuroinflammation and ameliorates bone cancer pain: involvement of inhibition on mitogen-activated protein kinase JO - Anesthesiology VL - 123 UR - https://doi.org/10.1097/ALN.0000000000000856 DO - 10.1097/ALN.0000000000000856 ID - Song2015 ER - TY - JOUR AU - Lu, C. AU - Liu, Y. AU - Sun, B. AU - Sun, Y. AU - Hou, B. AU - Zhang, Y. AU - Ma, Z. AU - Gu, X. PY - 2015 DA - 2015// TI - Intrathecal injection of JWH-015 attenuates bone cancer pain via time-dependent modification of pro-inflammatory cytokines expression and astrocytes activity in spinal cord JO - Inflammation VL - 38 UR - https://doi.org/10.1007/s10753-015-0168-3 DO - 10.1007/s10753-015-0168-3 ID - Lu2015 ER - TY - JOUR AU - Zhao, F. AU - Chen, Y. AU - Zeng, L. AU - Li, R. AU - Zeng, R. AU - Wen, L. AU - Liu, Y. AU - Zhang, C. PY - 2010 DA - 2010// TI - Role of triptolide in cell proliferation, cell cycle arrest, apoptosis and histone methylation in multiple myeloma U266 cells JO - Eur J Pharmacol VL - 646 UR - https://doi.org/10.1016/j.ejphar.2010.05.034 DO - 10.1016/j.ejphar.2010.05.034 ID - Zhao2010 ER - TY - JOUR AU - Wen, L. AU - Chen, Y. AU - Zeng, L. L. AU - Zhao, F. AU - Li, R. AU - Liu, Y. AU - Zhang, C. PY - 2012 DA - 2012// TI - Triptolide induces cell-cycle arrest and apoptosis of human multiple myeloma cells in vitro via altering expression of histone demethylase LSD1 and JMJD2B JO - Acta Pharmacol Sin VL - 33 UR - https://doi.org/10.1038/aps.2011.145 DO - 10.1038/aps.2011.145 ID - Wen2012 ER - TY - JOUR AU - Zimmermann, M. PY - 1983 DA - 1983// TI - Ethical guidelines for investigations of experimental pain in conscious animals JO - Pain VL - 16 UR - https://doi.org/10.1016/0304-3959(83)90201-4 DO - 10.1016/0304-3959(83)90201-4 ID - Zimmermann1983 ER - TY - JOUR AU - Kou, Z. Z. AU - Wan, F. P. AU - Bai, Y. AU - Li, C. Y. AU - JC, H. AU - Zhang, G. T. AU - Zhang, T. AU - Chen, T. AU - Wang, Y. Y. AU - Li, H. AU - Li, Y. Q. PY - 2016 DA - 2016// TI - Decreased endomorphin-2 and mu-opioid receptor in the spinal cord are associated with painful diabetic neuropathy JO - Front Mol Neurosci VL - 9 UR - https://doi.org/10.3389/fnmol.2016.00080 DO - 10.3389/fnmol.2016.00080 ID - Kou2016 ER - TY - JOUR AU - Miraucourt, L. S. AU - Peirs, C. AU - Dallel, R. AU - Voisin, D. L. PY - 2011 DA - 2011// TI - Glycine inhibitory dysfunction turns touch into pain through astrocyte-derived d-serine JO - Pain VL - 152 UR - https://doi.org/10.1016/j.pain.2011.02.021 DO - 10.1016/j.pain.2011.02.021 ID - Miraucourt2011 ER - TY - JOUR AU - Ji, R. R. AU - RWT, G. AU - Malcangio, M. AU - Strichartz, G. R. PY - 2009 DA - 2009// TI - MAP kinase and pain JO - Brain Res Rev VL - 60 UR - https://doi.org/10.1016/j.brainresrev.2008.12.011 DO - 10.1016/j.brainresrev.2008.12.011 ID - Ji2009 ER - TY - JOUR AU - Chugh, R. AU - Sangwan, V. AU - Patil, S. P. AU - Dudeja, V. AU - Dawra, R. K. AU - Banerjee, S. AU - Schumacher, R. J. AU - Blazar, B. R. AU - Georg, G. I. AU - Vickers, S. M. AU - Saluja, A. K. PY - 2012 DA - 2012// TI - A preclinical evaluation of Minnelide as a therapeutic agent against pancreatic cancer JO - Sci Transl Med VL - 4 UR - https://doi.org/10.1126/scitranslmed.3004334 DO - 10.1126/scitranslmed.3004334 ID - Chugh2012 ER - TY - JOUR AU - Banerjee, S. AU - Thayanithy, V. AU - Sangwan, V. AU - Mackenzie, T. N. AU - Saluja, A. K. AU - Subramanian, S. PY - 2013 DA - 2013// TI - Minnelide reduces tumor burden in preclinical models of osteosarcoma JO - Cancer Lett VL - 335 UR - https://doi.org/10.1016/j.canlet.2013.02.050 DO - 10.1016/j.canlet.2013.02.050 ID - Banerjee2013 ER - TY - JOUR AU - Brown, M. R. AU - Ramirez, J. D. PY - 2015 DA - 2015// TI - Neuroimmune mechanisms in cancer pain JO - Curr Opin Support Palliat Care VL - 9 UR - https://doi.org/10.1097/SPC.0000000000000140 DO - 10.1097/SPC.0000000000000140 ID - Brown2015 ER - TY - JOUR AU - Falk, S. AU - Dickenson, A. H. PY - 2014 DA - 2014// TI - Pain and nociception: mechanisms of cancer-induced bone pain JO - J Clin Oncol VL - 32 UR - https://doi.org/10.1200/JCO.2013.51.7219 DO - 10.1200/JCO.2013.51.7219 ID - Falk2014 ER - TY - JOUR AU - Pevida, M. AU - Gonzalez-Rodriguez, S. AU - Lastra, A. AU - Garcia-Suarez, O. AU - Hidalgo, A. AU - Menendez, L. AU - Baamonde, A. PY - 2014 DA - 2014// TI - Involvement of spinal chemokine CCL2 in the hyperalgesia evoked by bone cancer in mice: a role for astroglia and microglia JO - Cell Mol Neurobiol VL - 34 UR - https://doi.org/10.1007/s10571-013-9995-7 DO - 10.1007/s10571-013-9995-7 ID - Pevida2014 ER - TY - JOUR AU - JH, H. AU - Yang, J. P. AU - Liu, L. AU - Li, C. F. AU - Wang, L. N. AU - Ji, F. H. AU - Cheng, H. PY - 2012 DA - 2012// TI - Involvement of CX3CR1 in bone cancer pain through the activation of microglia p38 MAPK pathway in the spinal cord JO - Brain Res VL - 1465 UR - https://doi.org/10.1016/j.brainres.2012.05.020 DO - 10.1016/j.brainres.2012.05.020 ID - JH2012 ER - TY - JOUR AU - Mao-Ying, Q. L. AU - Wang, X. W. AU - Yang, C. J. AU - Li, X. AU - Mi, W. L. AU - GC, W. AU - Wang, Y. Q. PY - 2012 DA - 2012// TI - Robust spinal neuroinflammation mediates mechanical allodynia in Walker 256 induced bone cancer rats JO - Mol Brain VL - 5 UR - https://doi.org/10.1186/1756-6606-5-16 DO - 10.1186/1756-6606-5-16 ID - Mao-Ying2012 ER - TY - JOUR AU - Cheng, C. F. AU - Cheng, J. K. AU - Chen, C. Y. AU - Lien, C. C. AU - Chu, D. AU - Wang, S. Y. AU - Tsaur, M. L. PY - 2014 DA - 2014// TI - Mirror-image pain is mediated by nerve growth factor produced from tumor necrosis factor alpha-activated satellite glia after peripheral nerve injury JO - Pain VL - 155 UR - https://doi.org/10.1016/j.pain.2014.01.010 DO - 10.1016/j.pain.2014.01.010 ID - Cheng2014 ER - TY - JOUR AU - Cheng, C. F. AU - Cheng, J. K. AU - Chen, C. Y. AU - Rau, R. H. AU - Chang, Y. C. AU - Tsaur, M. L. PY - 2015 DA - 2015// TI - Nerve growth factor-induced synapse-like structures in contralateral sensory ganglia contribute to chronic mirror-image pain JO - Pain VL - 156 UR - https://doi.org/10.1097/j.pain.0000000000000280 DO - 10.1097/j.pain.0000000000000280 ID - Cheng2015 ER - TY - JOUR AU - Huang, D. AU - Yu, B. PY - 2010 DA - 2010// TI - The mirror-image pain: an unclered phenomenon and its possible mechanism JO - Neurosci Biobehav Rev VL - 34 UR - https://doi.org/10.1016/j.neubiorev.2009.10.011 DO - 10.1016/j.neubiorev.2009.10.011 ID - Huang2010 ER - TY - JOUR AU - Cui, D. AU - Hoshii, Y. AU - Kawano, H. AU - Sugiyama, S. AU - Gondo, T. AU - Liu, Y. AU - Ishihara, T. PY - 2007 DA - 2007// TI - Experimental AA amyloidosis in mice is inhibited by treatment with triptolide, a purified traditional Chinese medicine JO - Int Immunopharmacol VL - 7 UR - https://doi.org/10.1016/j.intimp.2007.05.007 DO - 10.1016/j.intimp.2007.05.007 ID - Cui2007 ER - TY - JOUR AU - Cui, Y. Q. AU - Wang, Q. AU - Zhang, D. M. AU - Wang, J. Y. AU - Xiao, B. AU - Zheng, Y. AU - Wang, X. M. PY - 2016 DA - 2016// TI - Triptolide rescues spatial memory deficits and amyloid-beta aggregation accompanied by inhibition of inflammatory responses and MAPKs activity in APP/PS1 transgenic mice JO - Curr Alzheimer Res VL - 13 UR - https://doi.org/10.2174/156720501303160217122803 DO - 10.2174/156720501303160217122803 ID - Cui2016 ER - TY - JOUR AU - Kyriakis, J. M. AU - Avruch, J. PY - 2012 DA - 2012// TI - Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update JO - Physiol Rev VL - 92 UR - https://doi.org/10.1152/physrev.00028.2011 DO - 10.1152/physrev.00028.2011 ID - Kyriakis2012 ER - TY - JOUR AU - Kaminska, B. AU - Gozdz, A. AU - Zawadzka, M. AU - Ellert-Miklaszewska, A. AU - Lipko, M. PY - 2009 DA - 2009// TI - MAPK signal transduction underlying brain inflammation and gliosis as therapeutic target JO - Anat Rec (Hoboken) VL - 292 UR - https://doi.org/10.1002/ar.21047 DO - 10.1002/ar.21047 ID - Kaminska2009 ER - TY - JOUR AU - Kim, E. K. AU - Choi, E. J. PY - 2015 DA - 2015// TI - Compromised MAPK signaling in human diseases: an update JO - Arch Toxicol VL - 89 UR - https://doi.org/10.1007/s00204-015-1472-2 DO - 10.1007/s00204-015-1472-2 ID - Kim2015 ER - TY - JOUR AU - Staszewski, O. AU - Prinz, M. PY - 2014 DA - 2014// TI - Glial epigenetics in neuroinflammation and neurodegeneration JO - Cell Tissue Res VL - 356 UR - https://doi.org/10.1007/s00441-014-1815-y DO - 10.1007/s00441-014-1815-y ID - Staszewski2014 ER - TY - JOUR AU - Kaminska, B. AU - Mota, M. AU - Pizzi, M. PY - 1862 DA - 1862// TI - Signal transduction and epigenetic mechanisms in the control of microglia activation during neuroinflammation JO - Biochim Biophys Acta VL - 2016 ID - Kaminska1862 ER - TY - JOUR AU - Wang, G. AU - Shi, Y. AU - Jiang, X. AU - Leak, R. K. AU - Hu, X. AU - Wu, Y. AU - Pu, H. AU - Li, W. W. AU - Tang, B. AU - Wang, Y. PY - 2015 DA - 2015// TI - HDAC inhibition prevents white matter injury by modulating microglia/macrophage polarization through the GSK3beta/PTEN/Akt axis JO - Proc Natl Acad Sci U S A VL - 112 UR - https://doi.org/10.1073/pnas.1501441112 DO - 10.1073/pnas.1501441112 ID - Wang2015 ER - TY - JOUR AU - Suh, H. S. AU - Choi, S. AU - Khattar, P. AU - Choi, N. AU - Lee, S. C. PY - 2010 DA - 2010// TI - Histone deacetylase inhibitors suppress the expression of inflammatory and innate immune response genes in human microglia and astrocytes JO - J NeuroImmune Pharmacol VL - 5 UR - https://doi.org/10.1007/s11481-010-9192-0 DO - 10.1007/s11481-010-9192-0 ID - Suh2010 ER - TY - JOUR AU - Descalzi, G. AU - Ikegami, D. AU - Ushijima, T. AU - Nestler, E. J. AU - Zachariou, V. AU - Narita, M. PY - 2015 DA - 2015// TI - Epigenetic mechanisms of chronic pain JO - Trends Neurosci VL - 38 UR - https://doi.org/10.1016/j.tins.2015.02.001 DO - 10.1016/j.tins.2015.02.001 ID - Descalzi2015 ER - TY - JOUR AU - Tran, L. AU - Schulkin, J. AU - Ligon, C. O. AU - Greenwood-Van Meerveld, B. PY - 2015 DA - 2015// TI - Epigenetic modulation of chronic anxiety and pain by histone deacetylation JO - Mol Psychiatry VL - 20 UR - https://doi.org/10.1038/mp.2014.122 DO - 10.1038/mp.2014.122 ID - Tran2015 ER -