Fig. 3
Effects of intrathecal T10 administration on bone cancer induced mechanical allodynia. a Intrathecal injection of T10 from day 7 to day 13 did not affect the PWTs of the sham-operated group. However, T10 dose-dependently alleviated the mechanical allodynia in the BCP rats. This effect was still observed 6 days after drug withdrawal at day 19. b The AUCs for different groups were calculated to perform statistical analysis. The dose-effect or log (dose)-effect curves for the analgesic effects of intrathecal T10 were shown in c and d. The ED50 of T10 on bone cancer-induced mechanical allodynia was 5.874 μg/kg. n = 8 per group, *p < 0.05 vs. BCP + vehicle group; # p < 0.05 vs. BCP + T10 3 μg/kg group