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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Inhibition of DAMP signaling as an effective adjunctive treatment strategy in pneumococcal meningitis

Fig. 3

a–c Effects of combined administration of anti-HMGB1 antibodies and dexamethasone or daptomycin in the adjuvant therapy of pneumococcal meningitis (PM). All infected mice were treated 21 h after infection with ceftriaxone; isotype antibodies were used as placebo control. Lumbar puncture and collection of clinical parameters (a), bacterial titers (b), and pathophysiological (c) parameters were done 24 h after the start of therapy. The line within each group of points represents the mean of the group. Gray bars represent results already shown in Fig. 1. The treatment groups in gray were compared to either CFX + dexamethasone and CFX + anti-HMGB1 + dexamethasone or CFX + daptomycin and CFX + anti-HMGB1 + daptomycin. Statistics were conducted using one-way ANOVA and Student-Newman-Keuls post hoc test. For the blood and cerebellar titer, the dotted line represents the lower detection limit at log(cfu) = 1. *p < 0.05 compared to CFX + anti-HMGB1; +p < 0.05 compared to CFX + anti-HMGB1 + dexamethasone; #p < 0.05 compared to CFX + anti-HMGB1 + daptomycin

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