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Fig. 10 | Journal of Neuroinflammation

Fig. 10

From: Peripheral immune tolerance alleviates the intracranial lipopolysaccharide injection-induced neuroinflammation and protects the dopaminergic neurons from neuroinflammation-related neurotoxicity

Fig. 10

Intracranial LPS injection-induced microglial activation was inhibited by peripheral immune tolerance preconditioning in the SN. Rats from four groups with or without peripheral LPS pre-treatment were sacrificed, and then, the brains were removed at 7, 14, and 28 days after striatal injection. The results displayed that peripheral immune tolerance pre-treatment relieved intracranial LPS injection-induced microglial activation with downregulated mRNA levels of ED-1. a–c The mRNA levels of ED-1 were quantified by qRT-PCR (n = 7, each group). *P < 0.05, ***P < 0.001 vs. control group. ##P < 0.01, ###P < 0.001 vs. PBS (i.p.) + LPS (striatum) group. The data are presented as the mean ± SEM

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Journal of Neuroinflammation

ISSN: 1742-2094