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Fig. 12 | Journal of Neuroinflammation

Fig. 12

From: Peripheral immune tolerance alleviates the intracranial lipopolysaccharide injection-induced neuroinflammation and protects the dopaminergic neurons from neuroinflammation-related neurotoxicity

Fig. 12

Peripheral immune tolerance pre-treated PD rats were protected from intracranial LPS injection-induced neurodegeneration with increased dopaminergic neuronal survival in the SN. Rats from four groups with or without peripheral LPS pre-treatment were sacrificed, and then, the brains were removed at 7, 14, and 28 days after striatal injection. The results implied that peripheral immune tolerance pre-treatment protected the PD rats from neuroinflammation-related neurodegeneration with upregulated mRNA levels of TH. a–c The mRNA levels of TH were quantified by qRT-PCR (n = 7, each group). **P < 0.01, ***P < 0.001 vs. control group. #P < 0.05 vs. PBS (i.p.) + LPS (striatum) group. The data are presented as the mean ± SEM

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Journal of Neuroinflammation

ISSN: 1742-2094