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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Peripheral immune tolerance alleviates the intracranial lipopolysaccharide injection-induced neuroinflammation and protects the dopaminergic neurons from neuroinflammation-related neurotoxicity

Fig. 4

. Repeated low-dose LPS intraperitoneal injection preconditioning did not cause dopaminergic neuronal loss in the SN. We carried out immunohistochemical staining of TH and stereological counting of TH-positive neurons in the non-intracranial injected SN of rats at 1, 7, 14, and 28 days after the peripheral LPS injection. There was no significant differences between the control group and any other time points of the LPS (i.p.) group in the total numbers of TH-positive cells. a Immunohistochemistry staining on frozen sections of TH in the control group and any other time points of the LPS (i.p.) group. b Total numbers of TH-positive neurons in the right SN collected by stereological counting (n = 3, each group). The data are presented as the mean ± SEM. Scale bars, 250 μm (40×), 100 μm (100×), and 25 μm (200×)

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Journal of Neuroinflammation

ISSN: 1742-2094