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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Peripheral immune tolerance alleviates the intracranial lipopolysaccharide injection-induced neuroinflammation and protects the dopaminergic neurons from neuroinflammation-related neurotoxicity

Fig. 6

Peripheral immune tolerance preconditioning downregulated intracranial LPS injection-induced expression profiles of TNF-α and IL-1β in the SN. Rats from four groups with or without peripheral LPS pre-treatment were sacrificed, and right SN was dissected out at time point of 1, 7, 14, and 28 days after striatal LPS injection for qRT-PCR analysis. The results showed that peripheral immune tolerance preconditioning downregulated the expression profiles of TNF-α at 1, 7, and 14 days, as well as the expression profiles of IL-1β only at 1 and 7 days after the intracranial LPS exposure. a–c The mRNA levels of TNF-α in the right SN were detected by qRT-PCR. d–f The mRNA levels of and IL-1β in the right SN were detected by qRT-PCR. *P < 0.05, **P < 0.01, ***P < 0.001 vs. control group. #P < 0.05, ##P < 0.01, ###P < 0.001 vs. PBS (i.p.) + LPS (striatum) group. The data are presented as the mean ± SEM (n = 7)

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Journal of Neuroinflammation

ISSN: 1742-2094