Skip to main content
Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Peripheral immune tolerance alleviates the intracranial lipopolysaccharide injection-induced neuroinflammation and protects the dopaminergic neurons from neuroinflammation-related neurotoxicity

Fig. 7

Peripheral immune tolerance preconditioning did not alter intracranial LPS injection-induced production of IL-10 and TGF-β in the SN. Rats from four groups with or without peripheral LPS pre-treatment were sacrificed, and right SN was dissected out at time point of 1, 7, 14, and 28 days after striatal LPS injection for ELISA analysis. The results indicated that the production of IL-10 was increased at 7 days after the intracranial LPS exposure, while there were no differences in our observation of IL-10 at any other time points as well as TGF-β at any time points between the PBS (i.p.) + LPS (striatum) group and the LPS (i.p.) + LPS (striatum) group. a–f The expression of IL-10 (a–c) and TGF-β (d–f) in the right SN were detected by ELISA. *P < 0.05, **P < 0.01, ***P < 0.001 vs. control group. #P < 0.05 vs. PBS (i.p.) + LPS (striatum) group. The data are presented as the mean ± SEM (n = 7)

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094