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Fig. 11 | Journal of Neuroinflammation

Fig. 11

From: Inhibiting the microglia activation improves the spatial memory and adult neurogenesis in rat hippocampus during 48 h of sleep deprivation

Fig. 11

Minocycline treatment improves the temozolomide induced alteration of the neurogenesis proteins during SD. Changes in the cell counts of the a Ki-67. b BrdU cells in DG region of the hippocampus. c Representable image displaying the changes in DCX expression. d Cell counts of DCX cells in the DG region of the hippocampus at proliferative stage, intermediate stage, and post-mitotic stage. e Changes in the NeuN expression in the DG region. f Relative mean pixel intensity of NeuN protein in the DG region of the hippocampus. g Representable image of the changes in the BDNF expression in DG, CA1, and CA3 region of the hippocampus. Changes in the relative mean pixel intensity of BDNF protein in the h DG. i CA1. j CA3 region of the hippocampus. α p < 0.05 when sleep deprived treated with TMZ compared to control treated with TMZ. β p < 0.05 when sleep deprived treated with TMZ and minocycline compared to sleep deprived treated with TMZ. Kruskal-Wallis with Dunn’s post hoc test was applied for statistical analysis of cell count. One-way ANOVA with Bonferroni post hoc test was used for statistical analysis of relative mean pixel intensity of NeuN and BDNF proteins

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