Fig. 12

Correlation analysis predicting the interaction between spatial memory, cytokines, activated microglia, and neurogenesis during SD. a Adult neurogenesis and spatial memory interaction as shown by correlating latency to reach the platform with the number of BrdU-positive cells, proliferative DCX positive cells, and relative mean pixel intensity of BDNF protein. Interaction between the adult neurogenesis and pro-inflammatory cytokines level as shown by correlation between b TNF-α level in hippocampus and the number of BrdU-positive cells, proliferative DCX positive cells, and relative mean pixel intensity of BDNF protein. c IL-1β level in hippocampus and the number of BrdU-positive cells, proliferative DCX positive cells, and the relative mean pixel intensity of BDNF protein. Finally, the interaction between neurogenesis and activated microglial cells as shown by d correlation of activated microglial cells count in the hippocampus with the number of BrdU-positive cells, proliferative DCX positive cells, and relative mean pixel intensity of BDNF protein