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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Inhibiting the microglia activation improves the spatial memory and adult neurogenesis in rat hippocampus during 48 h of sleep deprivation

Fig. 8

Minocycline improves temozolomide induced spatial memory decline and inflammatory cytokine levels in hippocampus during SD. a Track plot of memory test session and study parameters such as b latency. c Path length. d Path efficiency [with hidden platform]. e Track plot of memory test session and study parameters such as f number of entries. g Time spent [no hidden platform]. Fold changes in the inflammatory cytokines in the hippocampus. h TNF-α. i IL-1β. j IL-6. k IL-4. l IL-10. α p < 0.05 when sleep deprived treated with TMZ compared to control treated with TMZ. β p < 0.05 when sleep deprived treated with TMZ and minocycline compared to sleep deprived treated with TMZ. One-way ANOVA with Bonferroni post hoc test was applied for latency, path length to reach the platform, time spent in the target zone, cytokine levels, and Kruskal-Wallis with Dunn’s post hoc test for path efficiency to reach the platform, number of entries in the target zone

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