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Fig. 9 | Journal of Neuroinflammation

Fig. 9

From: Inhibiting the microglia activation improves the spatial memory and adult neurogenesis in rat hippocampus during 48 h of sleep deprivation

Fig. 9

Minocycline inhibited the temozolomide induced changes in glial cell immunoreactivity in rat hippocampus following SD. a Representable image of astrocyte expression in DG, CA1, and CA3 regions of the hippocampus. GFAP immunoreactivity quantification in b DG region. c CA1 region. d CA3 region of the hippocampus. e Representable image of microglial cells expression in DG, CA1, and CA3 regions of the hippocampus. Iba-1 cell immunoreactivity quantification in f DG region. g CA1 region. h CA3 region of the hippocampus. α p < 0.05 when sleep deprived treated with TMZ compared to control treated with TMZ. β p < 0.05 when sleep deprived treated with TMZ and minocycline compared to sleep deprived treated with TMZ. One-way ANOVA with Bonferroni post hoc test was used for statistical analysis

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Journal of Neuroinflammation

ISSN: 1742-2094