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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Selective depletion of microglial progranulin in mice is not sufficient to cause neuronal ceroid lipofuscinosis or neuroinflammation

Fig. 1

Grn expression is significantly reduced in microglia in Lyz-cKO mice. a Grn measured in whole brain lysate by ELISA. N = 10 Ctrl, 6 Lyz-cKO, and 4 GrnKO mice. b Grn mRNA measured by qRT-PCR in cortex RNA samples. N = 4 Ctrl, 3 Lyz-cKO, and 2 GrnKO mice. c Grn measured by ELISA in adult microglia isolated by flow cytometry. Microglia from 4 mice per genotype were pooled and run as a single sample in duplicate. d Grn mRNA measured by qRT-PCR in RNA extracted from adult microglia isolated by flow cytometry. N = 4 Ctrl, 4 Het, and 4 Lyz-cKO mice. Data represent mean ± SEM

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Journal of Neuroinflammation

ISSN: 1742-2094